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副教授 丁实
2019-04-16 08:17  

丁实,男,19866月出生,博士,副教授,硕士生导师,中国药学会高级会员。2009年毕业于华中科技大学同济药学院,获得药学学士学位;2015年毕业于中国科学院大学上海药物研究所,获得药物化学博士学位。20164月起开始在辽宁大学从事教学和科研的工作,主持国家自然科学基金项目1项,省教育厅项目1项,校级项目一项;参加国家、省、市级项目多项。以第一作者或通讯作者身份发表SCI论文10篇,以其他作者身份发表SCI论文10余篇,中文论文3篇。申请发明专利近20项,授权1项。主讲硕士研究生课程《高等有机化学》《药学设计与统计学》《研究方法论》《制药工艺与环境污染控制》。主讲本科生课程《临床药学》《医药市场营销》《消费心理学》。

主要研究方向:

1.      基于靶点的新药开发:如新型EGFR激酶抑制剂类抗肿瘤药物、LpxC抑制剂类抗革兰氏阴性菌药物、凝血因子Xa抑制剂类抗凝血药物的设计、合成及构效关系研究

2.      天然产物的全合成及结构修饰

3.      药物的制备工艺优化

主要论文:

1.      Ju Liu, Yilin Gong, Jiantao Shi, Xuechen Hao, Yang Wang, Yunpeng Zhou, Yunlei Hou, Yajing Liu, Shi Ding (corresponding author), Ye Chen. Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. European Journal of Medicinal Chemistry. 2020, 194, 112244.

2.      Ju Liu, Jian–Tao Shi, Yi-Lin Gong, Shi Ding (corresponding author), Ye Chen. Synthesis, crystal and antiproliferative activity of 2-[2-(2-fluorobenzylidene) hydrazinyl]-4-(1-methyl-1H-indol-3-yl)thieno[3,2-d]pyrimidine. Molecular Crystals and Liquid Crystals. 2019, 692(1), 53–61.

3.      Shi Ding (first author), Jing‐Chao Ji, Ming‐Juan Zhang, Yu‐She Yang, Rui Wang, Xing‐Long Zhu, Li‐Hong Wang, Yi Zhong, Le Gao, Man Lu, Ju Liu, Ye Chen. Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents. Arch Pharm Chem Life Sci., 2019, e1900129.

4.      Jian-Tao SHI, Yi-Lin GONG, Jun LI, Yang WANG, Ye CHEN, Shi DING (corresponding author), Ju LIU. Synthesis, Structure and Biological Activity of 2-[2-(4-Fluorobenzylidene)hydrazinyl]-4-(1-methyl-1H-indol-3-yl)thieno[3,2-d]pyrimidine. Chinese Journal of Structural Chemistry, 2019, 38 (9): 1530~1536.

5.      Yi-Lin GONG, Jian-Tao SHI, Yang WANG, Ye CHEN, Shi DING (corresponding author), Yang LIU, Ju LIU. Synthesis and Antiproliferative Activity of Novel Indazole Chalcone Hybrids. Chinese Journal of Applicated Chemistry, 2019, 36 (9):1015~1022.

6.      Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents. Bioorganic & Medicinal Chemistry Letters, 2018, 28(2): 94~102. (第一作者)

7.      Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. Bioorganic & Medicinal Chemistry Letters, 2015, 25(10): 2203~2210. (第一作者)

8.      Design, synthesis and biological evaluation of LpxC inhibitors with novel hydrophilic terminus. Chinese Chemical Letters, 2015, 26 (6): 763~767. (第一作者)

9.      Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel [6,6,5] Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor. Journal of Medicinal Chemistry, 2014, 57(18): 7770~7791.(第一作者)

10.  Synthesis, crystal structure and antitumour activity of ethyl 2-[(2-amino-3cyano-4-phenethyl-4H-naphtho[1,2-b]pyran-8-yl)oxy]acetate. Journal of Chemical Research, 2018, 42: 486~489.

11.  Synthesis, crystal structure and antitumour activity of 3-amino-N-(5-fluoro-2- methylphenyl)-4-morpholino-1H-indazole-1-carboxamide. Journal of Chemical Research, 2017, 41(11): 624~626.

12.  Synthesis of new substituted 5-amino-8H-phthalazino[1,2-b] quinazolin-8-one derivatives. Journal of Chemical Research, 2017, 41 (1):18~20.

13.  Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates. Bioorganic & Medicinal Chemistry Letters, 2012, 22(2): 814~819.

14.  First Scale-Up Synthesis of FU-23, a Novel Water-Soluble Pleuromutilin-Derived Antibiotic. Organic Process Research & Development, 2010, 14(4): 815~819.

15.  新型吡唑并[3, 4-b][1, 5]苯二氮杂䓬衍生物的合成,《辽宁大学学报》,20183期,244~248

16.  《叶酸受体介导的小分子抗肿瘤药物研究进展》,《中国药物化学杂志》,201303期,226~234页。

17.  《类风湿关节炎治疗靶点及药物研究进展》,《中国药师》, 200808期,908~910

 

联系方式:

地址:辽宁省沈阳市崇山中路66号,辽宁大学药学院

电话:024-62202469

传真:024-62202469

电邮:dingshi_destiny@163.com

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